A Linear Algebra Approach to Fast DNA Mixture Analysis Using GPUs

Analysis of DNA samples is an important step in forensics, and the speed of analysis can impact investigations. Comparison of DNA sequences is based on the analysis of short tandem repeats (STRs), which are short DNA sequences of 2-5 base pairs. Current forensics approaches use 20 STR loci for analysis. The use of single nucleotide polymorphisms (SNPs) has utility for analysis of complex DNA mixtures. The use of tens of thousands of SNPs loci for analysis poses significant computational challenges because the forensic analysis scales by the product of the loci count and number of DNA samples to be analyzed. In this paper, we discuss the implementation of a DNA sequence comparison algorithm by re-casting the algorithm in terms of linear algebra primitives. By developing an overloaded matrix multiplication approach to DNA comparisons, we can leverage advances in GPU hardware and algoithms for Dense Generalized Matrix-Multiply (DGEMM) to speed up DNA sample comparisons. We show that it is possible to compare 2048 unknown DNA samples with 20 million known samples in under 6 seconds using a NVIDIA K80 GPU.Comment: Accepted for publication at the 2017 IEEE High Performance Extreme Computing conferenc

Lincoln AI Computing Survey (LAICS) Update

This paper is an update of the survey of AI accelerators and processors from past four years, which is now called the Lincoln AI Computing Survey - LAICS (pronounced "lace"). As in past years, this paper collects and summarizes the current commercial accelerators that have been publicly announced with peak performance and peak power consumption numbers. The performance and power values are plotted on a scatter graph, and a number of dimensions and observations from the trends on this plot are again discussed and analyzed. Market segments are highlighted on the scatter plot, and zoomed plots of each segment are also included. Finally, a brief description of each of the new accelerators that have been added in the survey this year is included.Comment: 7 pages, 6 figures, 2023 IEEE High Performance Extreme Computing (HPEC) conference, September 202

AI and ML Accelerator Survey and Trends

This paper updates the survey of AI accelerators and processors from past three years. This paper collects and summarizes the current commercial accelerators that have been publicly announced with peak performance and power consumption numbers. The performance and power values are plotted on a scatter graph, and a number of dimensions and observations from the trends on this plot are again discussed and analyzed. Two new trends plots based on accelerator release dates are included in this year's paper, along with the additional trends of some neuromorphic, photonic, and memristor-based inference accelerators.Comment: 10 pages, 4 figures, 2022 IEEE High Performance Extreme Computing (HPEC) Conference. arXiv admin note: substantial text overlap with arXiv:2009.00993, arXiv:2109.0895

Streaming Graph Challenge: Stochastic Block Partition

An important objective for analyzing real-world graphs is to achieve scalable performance on large, streaming graphs. A challenging and relevant example is the graph partition problem. As a combinatorial problem, graph partition is NP-hard, but existing relaxation methods provide reasonable approximate solutions that can be scaled for large graphs. Competitive benchmarks and challenges have proven to be an effective means to advance state-of-the-art performance and foster community collaboration. This paper describes a graph partition challenge with a baseline partition algorithm of sub-quadratic complexity. The algorithm employs rigorous Bayesian inferential methods based on a statistical model that captures characteristics of the real-world graphs. This strong foundation enables the algorithm to address limitations of well-known graph partition approaches such as modularity maximization. This paper describes various aspects of the challenge including: (1) the data sets and streaming graph generator, (2) the baseline partition algorithm with pseudocode, (3) an argument for the correctness of parallelizing the Bayesian inference, (4) different parallel computation strategies such as node-based parallelism and matrix-based parallelism, (5) evaluation metrics for partition correctness and computational requirements, (6) preliminary timing of a Python-based demonstration code and the open source C++ code, and (7) considerations for partitioning the graph in streaming fashion. Data sets and source code for the algorithm as well as metrics, with detailed documentation are available at GraphChallenge.org.Comment: To be published in 2017 IEEE High Performance Extreme Computing Conference (HPEC

Layer-Parallel Training with GPU Concurrency of Deep Residual Neural Networks via Nonlinear Multigrid

A Multigrid Full Approximation Storage algorithm for solving Deep Residual Networks is developed to enable neural network parallelized layer-wise training and concurrent computational kernel execution on GPUs. This work demonstrates a 10.2x speedup over traditional layer-wise model parallelism techniques using the same number of compute units.Comment: 7 pages, 6 figures, 27 citations. Accepted to 2020 IEEE High Performance Extreme Computing Conference - Outstanding Paper Awar

Performance Measurements of Supercomputing and Cloud Storage Solutions

Increasing amounts of data from varied sources, particularly in the fields of machine learning and graph analytics, are causing storage requirements to grow rapidly. A variety of technologies exist for storing and sharing these data, ranging from parallel file systems used by supercomputers to distributed block storage systems found in clouds. Relatively few comparative measurements exist to inform decisions about which storage systems are best suited for particular tasks. This work provides these measurements for two of the most popular storage technologies: Lustre and Amazon S3. Lustre is an open-source, high performance, parallel file system used by many of the largest supercomputers in the world. Amazon's Simple Storage Service, or S3, is part of the Amazon Web Services offering, and offers a scalable, distributed option to store and retrieve data from anywhere on the Internet. Parallel processing is essential for achieving high performance on modern storage systems. The performance tests used span the gamut of parallel I/O scenarios, ranging from single-client, single-node Amazon S3 and Lustre performance to a large-scale, multi-client test designed to demonstrate the capabilities of a modern storage appliance under heavy load. These results show that, when parallel I/O is used correctly (i.e., many simultaneous read or write processes), full network bandwidth performance is achievable and ranged from 10 gigabits/s over a 10 GigE S3 connection to 0.35 terabits/s using Lustre on a 1200 port 10 GigE switch. These results demonstrate that S3 is well-suited to sharing vast quantities of data over the Internet, while Lustre is well-suited to processing large quantities of data locally.Comment: 5 pages, 4 figures, to appear in IEEE HPEC 201

Enabling On-Demand Database Computing with MIT SuperCloud Database Management System

The MIT SuperCloud database management system allows for rapid creation and flexible execution of a variety of the latest scientific databases, including Apache Accumulo and SciDB. It is designed to permit these databases to run on a High Performance Computing Cluster (HPCC) platform as seamlessly as any other HPCC job. It ensures the seamless migration of the databases to the resources assigned by the HPCC scheduler and centralized storage of the database files when not running. It also permits snapshotting of databases to allow researchers to experiment and push the limits of the technology without concerns for data or productivity loss if the database becomes unstable.Comment: 6 pages; accepted to IEEE High Performance Extreme Computing (HPEC) conference 2015. arXiv admin note: text overlap with arXiv:1406.492

Lustre, Hadoop, Accumulo

Data processing systems impose multiple views on data as it is processed by the system. These views include spreadsheets, databases, matrices, and graphs. There are a wide variety of technologies that can be used to store and process data through these different steps. The Lustre parallel file system, the Hadoop distributed file system, and the Accumulo database are all designed to address the largest and the most challenging data storage problems. There have been many ad-hoc comparisons of these technologies. This paper describes the foundational principles of each technology, provides simple models for assessing their capabilities, and compares the various technologies on a hypothetical common cluster. These comparisons indicate that Lustre provides 2x more storage capacity, is less likely to loose data during 3 simultaneous drive failures, and provides higher bandwidth on general purpose workloads. Hadoop can provide 4x greater read bandwidth on special purpose workloads. Accumulo provides 10,000x lower latency on random lookups than either Lustre or Hadoop but Accumulo's bulk bandwidth is 10x less. Significant recent work has been done to enable mix-and-match solutions that allow Lustre, Hadoop, and Accumulo to be combined in different ways.Comment: 6 pages; accepted to IEEE High Performance Extreme Computing conference, Waltham, MA, 201

Lessons Learned from a Decade of Providing Interactive, On-Demand High Performance Computing to Scientists and Engineers

For decades, the use of HPC systems was limited to those in the physical sciences who had mastered their domain in conjunction with a deep understanding of HPC architectures and algorithms. During these same decades, consumer computing device advances produced tablets and smartphones that allow millions of children to interactively develop and share code projects across the globe. As the HPC community faces the challenges associated with guiding researchers from disciplines using high productivity interactive tools to effective use of HPC systems, it seems appropriate to revisit the assumptions surrounding the necessary skills required for access to large computational systems. For over a decade, MIT Lincoln Laboratory has been supporting interactive, on-demand high performance computing by seamlessly integrating familiar high productivity tools to provide users with an increased number of design turns, rapid prototyping capability, and faster time to insight. In this paper, we discuss the lessons learned while supporting interactive, on-demand high performance computing from the perspectives of the users and the team supporting the users and the system. Building on these lessons, we present an overview of current needs and the technical solutions we are building to lower the barrier to entry for new users from the humanities, social, and biological sciences.Comment: 15 pages, 3 figures, First Workshop on Interactive High Performance Computing (WIHPC) 2018 held in conjunction with ISC High Performance 2018 in Frankfurt, German